a negative trendP = 0.552
Restricted cubic spline analysis revealed a positive linear relationship for the risk of limb ischemia (linear, P = 0.006; area under the receiver operating characteristic curve of 0.75 [95% CI, 0.656–0.848]), a U-shaped trend for bleeding events (nonlinear, P = 0.214), and a negative trend for thrombotic events (linear, P = 0.552).