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Nonessential amino acid is not nonessential in geriatric patients: implications for maxillofacial wound healing and bone repair.

Maxillofac Plast Reconstr Surg · 2025 · PMC12106272 · PMID 40418369

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showed a trendno p-value reported
Additionally, the metabolic balance of glutamine and glutamate is altered: nonhealing callus tissues showed a trend toward elevated glutamate levels, suggesting increased glutaminolysis to meet the heightened demand for proline and other biosynthetic precursors [ 95 ].

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