HDAC6 inhibition by ITF3756 modulates PD-L1 expression and monocyte phenotype: insights for a promising immune checkpoint blockade co-treatment therapy.

Front Immunol · 2025 · PMC12106391 · PMID 40433358

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In this context, ITF3756 showed a trend towards further increasing CD40 expression levels ( Figure 1A ), while it significantly downregulated both PD-L1 expression levels and the percentage of PD-L1 positive cells ( Figure 1B ).

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