Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice.

Nat Commun · 2025 · PMC12106843 · PMID 40419468

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In addition, CHD8 binding at regions marked by H3K27ac or H3K4me1 was increased in Chd8 KI mice, whereas no such difference was apparent for that at TSS and H3K4me3 regions, suggestive of increased binding of CHD8 to enhancer regions as a result of Chd8 overexpression (Supplementary Fig. 5e ).

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