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Pharmacological Blocking of Adiponectin Receptors Induces Alzheimer's Disease-like Neuropathology and Impairs Hippocampal Function.

Biomedicines · 2025 · PMC12109274 · PMID 40426884

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Additionally, there was a noticeable trend toward reduced expression of PP2A mRNA ( Figure 2 C; two-sample t -test: t (6) = 2.428, p = 0.0513) and GSK-3β mRNA ( Figure 2 D; two-sample t -test: t (6) = 1.576, p = 0.1661) in the ADP400-treated group compared to the control group, although these differences did not reach statistical significance.

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a decreasing trendno p-value reported
Our results demonstrated a decreasing trend in both PP2A and GSK3β mRNA expression in ADP400-treated mice.

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