The Impact of Resection Margins in Primary Resection of High-Grade Soft Tissue Sarcomas: How Far Is Far Enough?

There was a significant difference in LRFS between patients with resection margins of ≥0–1 mm and >1–5 mm ( p = 0.07), and this difference showed a trend when adjuvant radiotherapy was applied ( p = 0.137).

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Both margin width and adjuvant radiotherapy had a highly significant positive impact on LRFS ( Table 3 , Figure 1 and Figure 2 ), with the hazard ratio decreasing as the diameter of the surrounding non-reactive tissue increased.

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