Epitranscriptomic Analysis of the Ventral Hippocampus in a Mouse Model of Post-Traumatic Stress Disorder Following Deep Brain Stimulation Treatment of the Basolateral Amygdala.

FS and DBS Induced Alterations in m 6 A Methylation Levels in vHPC We first measured the levels of Mettl3 (m 6 A writer) using Western blotting and found that the levels of Mettl3 were significantly higher in the FS mice compared to the Ctrl group (42.4% increase), and these levels showed an increasing trend in the FS-DBS group compared to the FS group (19.3% increase) ( Figure 2 A).

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We performed a correlation analysis between gene expression and epigenetic modifications and found that the “m 6 A methylation level”, calculated as the percentage of modified RNA per transcript, did not show a clear trend in correlation with gene expression ( Figure S2A,B ).

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