TIMP1 Overexpression in Ovarian Cancer Spheroids: Implications for Prognosis, Resistance, and Metastatic Potential.

Cancers (Basel) · 2025 · PMC12109905 · PMID 40427104

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TIMP1 overexpression significantly increased ALDH1, CD44, and NANOG expression in Ovcar5 cells, while in Ovcar8 cells, it significantly enhanced NANOG and CD44 expression and showed a trend toward increased ALDH1 expression, although not reaching statistical significance ( Figure 8 A,B).

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