Real-World Use of COMT Inhibitors in the Management of Patients with Parkinson's Disease in Spain Who Present Early Motor Fluctuations: Interim Results from the REONPARK Study.

Brain Sci · 2025 · PMC12110095 · PMID 40426702

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

showed a trendno p-value reported

The ADOPTION study, conducted in a cohort of patients showing early fluctuations similar to our patients, showed a trend for greater improvements in Part III with opicapone (−3.4) compared with levodopa at 100 mg (−2.5) in the first month and a greater reduction in the percentage of OFF time ( p = 0.0015) [ 19 ].

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.