Molecular Interplay Between PTEN, ARID1A, PD-L1, and MMR in Asian Ovarian Clear Cell Carcinoma: Implications for Immunotherapy Response and Patient Stratification.

Int J Mol Sci · 2025 · PMC12112434 · PMID 40430056

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.3330

boldest claim

The sentences

borderline significancep = 0.056so close (0.05 < p ≤ 0.1)

This trend was also observed in the overall cohort, though with borderline significance ( p = 0.056).

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did not reach statistical significancep = 0.333not close (p > 0.1)

Strikingly, all dMMR tumors (100%) showed PTEN loss, compared to 75.8% of pMMR tumors, although this difference did not reach statistical significance ( p = 0.333).

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