Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial.

Furthermore, when evaluating the percentage of days of abnormal bowel movements, where a day with normal bowel movements is defined as a day with less than or equal to three bowel movements per day with normal stool consistency (Bristol stool scale 3–5), in the PP population, patients in the placebo group showed a trend toward improvement during treatment but without significant results and an increase in abnormal days at week 16, which was numerically higher when compared to baseline levels ( Figure 5 ).

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