DPYD Genotyping, Fluoropyrimidine Dosage and Toxicity: An Umbrella Review of Systematic Reviews.

Pharmaceuticals (Basel) · 2025 · PMC12115295 · PMID 40430545

Europe PMC DOI

hedged sentence

0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

did not reach statistical significancep = 0.062so close (0.05 < p ≤ 0.1)

However, in 5-FU bolus treatment, DPYD2A did not reach statistical significance for global toxicity (OR 0.7, 95% CI 0.5–1.0, p = 0.062).

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