Predictive factors for efficacy of oxaliplatin-based chemotherapy in advanced well-differentiated neuroendocrine tumors: an observational cohort study and meta-analysis.

Front Endocrinol (Lausanne) · 2025 · PMC12116336 · PMID 40438391

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.4500

boldest claim

The sentences

marginal significancep = 0.07so close (0.05 < p ≤ 0.1)

Although the significance of higher chemotherapy response in pNET was lost when low-quality studies were excluded in a sensitivity analysis, the effect was still suggestive (OR = 0.45, 95%CI: 0.19–1.07) and approaching the threshold for marginal significance ( p = 0.07) ( 6 ).

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showed a trendp = 0.45not close (p > 0.1)

In terms of impact of location on efficacy, pancreatic NETs showed a trend of higher ORR (33.3% vs. 22.2%, p = 0.45) than extra-pancreatic NETs in this cohort.

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