Deciphering linezolid-induced hematologic toxicity: Targeting TOP2A and TOP2B via its primary metabolite PNU142586.

Sci Adv · 2025 · PMC12118551 · PMID 40435237

Europe PMC DOI

hedged sentence

0.0710

closest p · 1.4× alpha

0.0710

boldest claim

The sentences

marginally significantP = 0.071so close (0.05 < p ≤ 0.1)

did not reach statistical significanceno p-value reported

However, because of the sample size of 84 patients (22 with toxicity versus 62 without toxicity), the results did not reach statistical significance but were marginally significant ( P = 0.071 for LZD and P = 0.079 for PNU142586), indicating the need for a larger clinical study to clarify these findings.

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