Selective Glycopolymer Inhibitors of Galectin-3: Supportive Anti-Cancer Agents Protecting Monocytes and Preserving Interferon-Gamma Function.

We conclude that the most important parameter is the density of the ligands across the polymer chain, not the length of the polymer chains in such a short size window. As for the selectivity of inhibition compared to the other abundant galectin Gal-1 ( Supporting Information , Table S3 ), the increase in affinity with the increasing glycan content was a clear trend that applied to all glycan motifs.

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