Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer's disease progression.

Sci Adv · 2025 · PMC12118632 · PMID 40435260

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showed a trendno p-value reported

Flow cytometry analysis showed a trend to increase the proportion of phagocytic microglia in Egln3 −/− ; APP-PSEN1/+ compared with those in APP-PSEN1/+ mice ( Fig. 5D ).

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