Effect of biologic treatments on growth in children with juvenile idiopathic arthritis: A systematic review.

PLoS One · 2025 · PMC12118834 · PMID 40435201

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did not reach statistical significanceno p-value reported

An increase in IGF-1 levels was observed in both prepubertal and pubertal children [ 19 ], but while the majority of prepubertal and pubertal patients experienced growth improvement after treatment with Etanercept, the growth improvement in the pubertal group did not reach statistical significance [ 20 ].

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