nearly statistically significantP = 0.0640
For the CAL, significant reductions were observed in the test group at P+2 ( P = 0.0027) and P+3 ( P = 0.0019) as compared to the P-2 baseline, and in the placebo group at P0 ( P = 0.0049), P+2 ( P = 0.0017), and P+3 ( P ≤ 0.0001); at P0 in the test group, the reduction of CAL was nearly statistically significant ( P = 0.0640).