Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers.

Nat Commun · 2025 · PMC12119811 · PMID 40436851

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nominally significantno p-value reported

For the EstBB replication set ( n = 92,645 individuals), 99.0% of the 2,019 available variants showed the same direction of effect, and 91.3% of these effects were nominally significant.

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highly significantno p-value reported

These models produced highly significant associations with BMI, sex, and their interaction across nearly all metabolites, as summarized in Supplementary Data 12 .

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