Barely Significant
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Serum alpha-klotho levels associate with bone mineral density in chronic kidney disease patients from NHANES 2011 to 2016.

Sci Rep · 2025 · PMC12120104 · PMID 40436995

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0.0060
closest p · 0.1× alpha
0.0060
boldest claim

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showed a trendp = 0.006actually significant
Renal function-related indices also demonstrated significant associations, with serum creatinine levels decreasing significantly ( p < 0.001) with increasing α-klotho levels, from 82.20 ± 55.43 umol/L in Q1 to 68.35 ± 25.71 umol/L in Q4; similarly, uric acid levels showed a significant decreasing trend ( p < 0.001) from 336.06 in Q1 ± 85.56 umol/L to 289.05 ± 82.82 umol/L in Q4.Blood urea nitrogen likewise showed a trend of negative correlation ( p = 0.006) with α-klotho level from 5.13 ± 2.33 mmol/L in Q1 to 4.57 ± 1.67 mmol/L in Q4.

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