NKX2-5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation.

Adv Sci (Weinh) · 2025 · PMC12120717 · PMID 40307990

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0.1100

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did not reach statistical significanceP = 0.11not close (p > 0.1)

While our SCH cohort did not reach statistical significance in terms of survival difference (log‐rank P = 0.11), a trend toward inferior survival was still apparent in the high‐activity group compared with the low‐activity group (Figure 6C ), further corroborating the prognostic value of this regulatory axis in ESCC.

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