Caspase-6/Gasdermin C-Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2-Dependent Recruitment of Myeloid-Derived Suppressor Cells.

Adv Sci (Weinh) · 2025 · PMC12120772 · PMID 40213993

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Overexpression of GSDMC2‐4 in CT26 cells showed a trend but no significant difference in promoting tumor growth in nude mice; however, knockdown of GSDMC2‐4 inhibited tumor growth (Figure S6H , Supporting Information).

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