Consistently, FMT markedly reduced the mRNA expression of Ccr7 and exhibited a decreasing trend in the mRNA levels of Cd38 , S1pr1 , and Ebi2 in the kidney (Figure 3I ).
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Microbiota-Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration.
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Similar to our FMT results, immune profiling revealed an increasing trend in naïve T cells and a decreasing trend in memory T cells in CD4 + T cells (Figure 5H ) and CD8 + T cells systemically (Figure 5H ).
While inosine levels displayed a negative correlation with the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI‐2K) scores, this relationship did not reach statistical significance (Figure S10G , Supporting Information).