The impact of oral cannabis consumption during pregnancy on maternal spiral artery remodelling, fetal growth and offspring behaviour in mice.

Interestingly, cytokine analysis of decidua supernatants showed a trend for elevated levels of MIP-1α and IL-15, both of which have been implicated in uNK cell recruitment, in CBD treated mice ( Fig. 1 n and o). 48 , 49 Thus, the slightly elevated levels of IL-15 and MIP-1α may possibly explain the elevated number of uNK cells we observe in pregnant mice exposed to CBD oil.

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While there is a slight trend for lower placental area in the THC oil treated mice, there is a significant reduction in placental area in the mice treated with CBD oil ( Fig. 1 b and c).

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