Mitochondrial fatty acid synthesis and MECR regulate CD4+ T cell function and oxidative metabolism.

In addition, the iTreg associated transcription factor FoxP3 showed an elevated trend with MECR deficiency ( Fig. 3F ), and IL-10 production was increased in MECR-deficient iTregs as measured by enzyme-linked immunosorbent assay ( Fig. 3G ).

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In addition, the percentages of IL-17a + IFNγ + and IL-17a + IFNγ − T cells showed a trend to decrease ( Fig.

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