Atherosclerotic Plaque Progression and Incident Cardiovascular Events in a 10-Year Prospective Study of Patients With Systemic Lupus Erythematosus: The Impact of Persistent Cardiovascular Risk Factor Target Attainment and Sustained DORIS Remission.

Arthritis Rheumatol · 2025 · PMC12123254 · PMID 39721769

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.6920

boldest claim

The sentences

a trend toward significanceP = 0.050actually significant

showed a trendP = 0.050actually significant

Baseline SCORE2 had a marginal statistical significance (hazard ratio [HR] 1.17, 95% CI 1.00–1.36, P = 0.048), whereas SCORE showed a trend toward significance for CVD events (HR 1.26, 95% CI 0.99–1.60, P = 0.050).

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did not reach statistical significanceP > 0.692not close (p > 0.1)

The interaction of patients with SLE and HCs with the sum of CVRF targets did not reach statistical significance (for interaction, P > 0.692 in all models), suggesting a beneficial effect of CVRF target attainment in both groups.

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marginally significantno p-value reported

Regarding the generic CVD risk prediction tools, although there was a marginally significant association between SCORE2 and CVD events and a trend toward significance between SCORE and CVD events in univariate analysis, both tools had limitations in their predictive ability.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.