Multi-omics analysis of Helicobacter pylori-associated gastric cancer identifies hub genes as a novel therapeutic biomarker.

S3B ) highlighted varied prognostic impacts of high expression levels, with CCR3 showing a significant association with poorer survival (log-rank P = .035, HR = 1.4, 95% CI: 0.98–2.00), while other genes such as CD80 ( P = .39, HR = 1.31, 95% CI: 0.92–1.87), CCR9 ( P = .21, HR = 1.42, 95% CI: 0.99–2.03), CCL20 ( P = .33, HR = 0.82, 95% CI: 0.58–1.17), CXCL1 ( P = .064, HR = 0.77, 95% CI: 0.54–1.10), CXCR6 ( P = .23, HR = 0.82, 95% CI: 0.58–1.16), CXCR3 ( P = .96, HR = 0.82, 95% CI: 0.58–1.16), and CXCR5 ( P = .77, HR = 1.07, 95% CI: 0.75–1.52) did not reach statistical significance.

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S3D ) confirmed significant expression differences between risk groups, with CXCL1 ( P = 3.46e-06, Student’s t -test) and CCL20 ( P = 4.54e-06, Student’s t -test) showing highly significant upregulation in the high-risk group, further validating their prognostic relevance.

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