The Combination of PARP and Topoisomerase 1 Inhibitors Improves Radiation Therapy for Ewing Sarcoma.

Cancer Sci · 2025 · PMC12127087 · PMID 40069935

Europe PMC DOI

hedged sentence

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

One of six mice treated with IRN alone experienced a partial response (PR), and although the median survival for this cohort was 26 days, the improvement in OS did not reach statistical significance when compared to the OS with RT alone ( p = 0.08).

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