Serum and plasma sphingolipids as biomarkers of chemotherapy-induced cardiotoxicity in female patients with breast cancer.

In contrast, comparisons of serum SL levels with GLS showed more promising results; at midpoint, there were significant correlations of S1P (r = 0.570, P = 0.005), dihydroS1P (r = 0.569, P = 0.007) and ahCer (r = 0.583, P = 0.020) although at the post-chemotherapy time-point, there was only significant correlations with S1P (r = 0.500, P = 0.034) and, again, borderline significance for ahCer (r = 0.486, P = 0.053).

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However, at the post-chemotherapy endpoint, there were significant negative correlations with serum S1P levels and LVEF (r = −0.488, P = 0.016) with ahCer again showing borderline significant (r = −0.425, P = 0.054).

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2 ), there were significant negative correlations with baseline serum levels of S1P (r = −0.485, P = 0.038) and dihydroS1P (r = −0.489, P = 0.034) with a negative, but marginally insignificant correlation observed for ahCer (r = −0.449, P = 0.067).

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This analysis revealed that baseline pro-NT-BNP levels negatively correlated with LVEF changes but this was not quite statistically significant (r = −0.469, P = 0.082).

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Analysis of the serum C16: C24-Cer ratio showed no significant correlation with changes in LVEF at baseline (r = −0.099, P = 0.798), midpoint (r = −0.271, P = 0.329), or post-chemotherapy (r = −0.436, P = 0.098) although it should be noted that the correlation was approaching significance at post-therapy.

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