Progressive accumulation of circulating CD27-CD28- effector/memory CD8+ T cells in patients with lung cancer blunts responses to immune checkpoint inhibitor therapy.

Exp Mol Med · 2025 · PMC12130471 · PMID 40307573

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difference was apparentno p-value reported

Interestingly, a marked difference was apparent especially at relatively earlier pseudotime points for C3.DN-Tem-CO , as evidenced by a substantially higher fraction of cells in patients than in healthy individuals (Fig. 3a , gray box).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Progressive accumulation of circulating CD27&lt;sup&gt;-&lt;/sup&gt;CD28&lt;sup&gt;-&lt;/sup&gt; effector/memory CD8&lt;sup&gt;+&lt;/sup&gt; T cells in patients with lung cancer blunts responses to immune checkpoint inhibitor therapy.

The sentences

Progressive accumulation of circulating CD27<sup>-</sup>CD28<sup>-</sup> effector/memory CD8<sup>+</sup> T cells in patients with lung cancer blunts responses to immune checkpoint inhibitor therapy.