Acute experimental colitis in 5xFAD Alzheimer's disease mice leads to enhanced monocyte infiltration into the brain accompanied by reduced β-amyloid deposition.

Hippocampal IL‐4 levels trended upward due to acute colitis, but they did not reach statistical significance. 3.3 Acute colitis in 5xFAD reduces beta‐amyloid deposition in the brain Next, we performed immunofluorescence on brain tissue sections for beta‐amyloid using the antibody 4G8 (Figure 4A ) and quantified the percent positive area in the cortex and hippocampus.

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