Mediating Role of Blood Metabolites in the Relationship Between Immune Cell Traits and Heart Failure: A Mendelian Randomization and Mediation Analysis.

34 For immune cell traits analyses, given the 731 MR estimates, a Bonferroni‐corrected P value was set as 0.05/731 (6.84e−5); for metabolites analyses, given the 1400 MR estimates, a Bonferroni‐corrected P value was set as 0.05/1400 (3.57e−5), and meanwhile P <0.05 was regarded as nominally significant. 35 , 36 RESULTS Strength of IVs This study examined the potential causal relationships between 731 circulating immune phenotypes, 1400 metabolites, and the risk of HF, using P <5e‐8 and F ‐statistics >10 as selection criteria.

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