Psychosocial Stress and Risk for Intracerebral Hemorrhage in the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) Study.

The INTERSTROKE study previously reported, among 3000 stroke cases (of which 663 were ICH) and 3000 controls, that psychosocial stress was associated with an increased risk for all stroke, but did not reach statistical significance in multivariable analysis for ICH alone. 8 A meta‐analysis utilizing 14 studies (10 prospective cohort and 4 case–control studies) for a total of 10 130 strokes demonstrated that the relationship between perceived psychosocial stress and risk of stroke was significant and found an increased risk of incident stroke, fatal stroke among all types, total ischemic stroke, and, most notably, an increased risk of total hemorrhage stroke.

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