Angiographic Quantitative Flow Ratio-Guided Treatment of Patients With Physiologically Intermediate Coronary Lesions.

Ischemia‐driven revascularization was performed in 18 (4.1%) patients in the QFR‐guided group and in 19 (4.5%) patients in the angiography‐guided group (HR, 0.91 [95% CI, 0.48–1.73]), and there was a borderline significant interaction between the relative treatment effect on ischemia‐driven revascularization before (2.2% versus 1.2%; HR, 1.90 [95% CI, 0.65–5.57]) and after (1.8% versus 3.6%; HR, 0.51 [95% CI, 0.22–1.20]) 1 year ( P interaction =0.06) (Figure S5 ).

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Nonstandard Abbreviations and Acronyms FFR fractional flow reserve MACE major adverse cardiac event PMI procedural myocardial infarction QFR quantitative flow ratio Clinical Perspective What Is New? The 2‐year risk of major adverse cardiac events between quantitative flow ratio– and angiography‐guided revascularization strategy did not reach statistical significance in the modest‐sized uncertainty‐zone subgroup.

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