Early Initiation of Sodium-Glucose Cotransporter 2 Inhibitors in Acute Heart Failure: A Systematic Review and Meta-Analysis.

J Am Heart Assoc · 2025 · PMC12132883 · PMID 40194974

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did not reach statistical significanceno p-value reported

Both sensitivity analyses, focusing on treatment initiation within the first 24 hours, and after exclusion of open‐label RCTs (342 patients), did not reach statistical significance for any of the efficacy or safety outcomes (Figures S2 and S3 ).

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