Estimating Cancer Penetrance in Carriers of BRCA2 Pathogenic Variants Using Cancer-Specific Polygenic Scores.

Cancer Med · 2025 · PMC12133613 · PMID 40462315

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0.0001

closest p · 0.0× alpha

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The sentences

failed to reach statistical significancep < 1E‐04actually significant

For some of these cancers, increased risk was observed in our study, but failed to reach statistical significance after the Bonferroni correction for 53 tests ( p < 1E‐04), including stomach (HR = 2.10, p = 0.03), esophagus (HR = 2.07, p = 0.02), and uterine cancer (HR = 1.69, p = 0.05).

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