Subtype-specific dysregulation of biogenic amine-related genes and miRNAs in breast cancer: identification of DRD2, HRH2, and HRH4 as potential therapeutic targets in TNBC and HER2+ subtypes.

Breast Cancer Res Treat · 2025 · PMC12133955 · PMID 40425926

Europe PMC DOI

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highly significantp-value < 1.0e−16actually significant

Functional network analysis of BAs: insights from protein–protein interaction (PPI) analysis The PPI analysis conducted using the STRING database revealed a highly significant enrichment of interactions among the analyzed proteins (PPI enrichment p-value < 1.0e−16), indicating a biologically relevant network rather than a random association.

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a decreasing trendno p-value reported

ICAM1 and MAPK9 displayed consistent overexpression, while OXT and SIRT4 showed moderate increases, with SIRT4 exhibiting a decreasing trend from luminal to TNBC subtypes.

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did not reach statistical significanceno p-value reported

Interestingly, we observed HRH1 overexpression across all breast cancer subtypes, with varying differences in overall survival, though these trends did not reach statistical significance.

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