A Landmark Multiyear Study of Alzheimer Disease: Integrating [18F]FEPPA PET Imaging With 12 Clinical Assessments for Comprehensive Disease Profiling.

Clin Nucl Med · 2025 · PMC12134464 · PMID 40462320

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0567

boldest claim

The sentences

highly significantP < 0.0001actually significant

However, the overall regression model was highly significant ( P < 0.0001), indicating that disease classification is a key determinant of PET signal variability.

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a strong tendency toward significanceP < 0.0567so close (0.05 < p ≤ 0.1)

However, there was a strong tendency toward significance in the temporal lobe ( P < 0.0567) and occipital lobe ( P < 0.0870), though statistical significance was not reached.

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did not reach statistical significanceno p-value reported

56 – 58 Although the mBNT did not reach statistical significance, trends in the temporal and occipital lobes suggest a possible association between naming impairments and regional neuroinflammation, warranting further investigation. 59 In line with prior studies demonstrating that glucose hypometabolism, amyloid deposition, and reduced gray matter volume contrib

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