The KasA inhibitor JSF-3285 improves the sterilizing activity of bedaquiline-pretomanid-containing regimens in a mouse model of tuberculosis.

Antimicrob Agents Chemother · 2025 · PMC12135538 · PMID 40265947

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0.0857

closest p · 1.7× alpha

0.0857

boldest claim

The sentences

did not quite reach statistical significanceP = 0.0857so close (0.05 < p ≤ 0.1)

After 2 months, the additive effect of JSF-3285 with BCM was maintained but did not quite reach statistical significance ( P = 0.0857) ( Fig. 5B ).

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did not reach statistical significanceno p-value reported

Unlike the statistically significant CFU reductions observed when JSF-3285 was added to BPa and BPaL in Experiment 3, the CFU reductions observed with the same regimen modification did not reach statistical significance after 1 month of treatment in Experiment 4 ( Table 3 ).

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