Barely Significant
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Longitudinal changes in each retinal layer thickness in patients with moderate or more severe diabetic retinopathy taking calcium dobesilate.

PLoS One · 2025 · PMC12136402 · PMID 40465771

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Additionally, it is crucial to note that the difference in thickness change between the two groups did not reach statistical significance, possibly due to the limited sample size in Group 1 or the inherently slow rate of reduction, resulting in a smaller difference.

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