Composite Confirmed Disability Worsening/Progression Is a Useful Clinical Endpoint for Multiple Sclerosis Clinical Trials.

Neurology · 2025 · PMC12136489 · PMID 40258203

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did not reach statistical significanceno p-value reported

Specifically, in all study arms and particularly PMS studies, the onset of T25FWT and 9HPT events was strongly and positively associated with an increased risk of confirmed EDSS events, which, only when these events were rare, did not reach statistical significance.

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