ELF1-mediated transactivation of METTL3/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration.

Cell Death Discov · 2025 · PMC12137937 · PMID 40467575

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showed a trendno p-value reported

More interestingly, it was found that a total of 931 genes showed a trend towards persistent m6A methylation during the senescence of the NPC [ 23 , 43 ].

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