Clinical studies have shown that in most samples from patients with RA, the translocation activity of GRK2 shows a significant trend of enhancement and is positively correlated with several serological RA biomarkers, further confirming its importance in the pathological process of RA.
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GRK2 activates TRAF2-NF-<i>κ</i>B signalling to promote hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis.
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