Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases.

Alzheimers Dement · 2025 · PMC12138277 · PMID 40469052

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approached significanceno p-value reported

In contrast, one SomaScan target for legumain (protein symbol: LGMN) exhibited a negative correlation with p‐tau181 that reached significance ( rho = −0.23, p < 0.001), whereas two additional LGMN targets and CTSD exhibited negative correlations with p‐tau181 that approached significance ( rho range: −0.10 to −0.11, p range: 0.090 to 0.053).

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