Stroke Prevention With Oral Anticoagulants in High-Risk Atrial Fibrillation in an Aging Population.

24 , 25 , 26 , 27 In patients aged ≥75 years, compared with warfarin, dabigatran 150 mg twice a day showed a trend toward higher risk of major bleeding, and dabigatran 110 mg twice a day showed a similar bleeding risk. 25 Rivaroxaban vs warfarin showed a similar risk of major bleeding in patients aged ≥75 years. 26 In contrast, apixaban vs warfarin showed a significantly lower rate of major bleeding in patients

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