Transmitted/founder (T/F) HIV-1 derived from sexual contact exhibits greater transmission fitness in human cervical tissue than T/F HIV-1 from blood-to-blood contact: Unique glycan profiles on T/F envelopes associated with transmission phenotypes.

PLoS Pathog · 2025 · PMC12140434 · PMID 40408432

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did not reach statistical significanceno p-value reported

The PWID chimeras had lower fitness than the MSM chimeras in cervical tissue based on a paired two-tailed Mann-Whitney (P = 0.0379) but did not reach statistical significance when considering all potential pairs using Dunn’s multiple comparison test ( Fig 3F and 3G ).

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