Barely Significant
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PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis.

Blood Adv · 2025 · PMC12141904 · PMID 39825858

Europe PMCDOI
1
hedged sentence
0.0550
closest p · 1.1× alpha
0.0550
boldest claim

The sentences

approached significanceP = .055so close (0.05 < p ≤ 0.1)
Plasma levels of the acute-phase reactant ferritin increased in mice with untreated secondary HLH, improved with ruxolitinib treatment, and revealed significant reduction in mice treated with PRT382 that was started on day 4, whereas earlier initiation of PRT382 on day 0 trended toward improvement and approached significance ( P = .055; supplemental Figure 4 B).

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