Antibody-Drug Conjugate Stability Probed by Variable-Temperature Electrospray Ionization Mass Spectrometry.

J Am Soc Mass Spectrom · 2025 · PMC12142670 · PMID 40408263

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a clear trendno p-value reported

Thus, there is a clear trend observed in the thermal stability of the cysteine-coupled ADCs; the higher is the drug load, the lower are the observed T 1/2 values, for both brentuximab vedotin and enfortumab vedotin.

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