Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods.

Mol Ther Nucleic Acids · 2025 · PMC12143625 · PMID 40487354

Europe PMC DOI

hedged sentences

0.0545

closest p · 1.1× alpha

0.0545

boldest claim

The sentences

almost reached significancep = 0.0545so close (0.05 < p ≤ 0.1)

The elevation of tRF-TyrGTA 1–19 levels in plasma of SM patients compared to ICH patients almost reached significance ( p = 0.0545), and a trend for elevated tRF-TyrGTA 1–19 levels was observed for IS patients when compared to ICH patients ( p = 0.1041).

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showed a trendno p-value reported

Out of 12 measured tRFs, only the fragments ArgTCG 53–67 and TyrGTA 1–19 showed a trend for differential expression between stroke subtypes, but with insufficient predictive value to be of use in clinical practice.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.