When compared to sorafenib, some of the compounds synthesized exhibited superior cytotoxic activity against hepatocellular carcinoma (HepG-2), with compounds 3 and 4 showing quite significant efficacy, as evidenced by their IC 50 values of 0.102 ± 0.04 and 0.058 ± 0.003 μM against HepG-2, respectively.
← all excerpts
Recent advances in the investigation of the quinazoline nucleus and derivatives with potential anticancer activities.
1
—
—